Scientific Image of a Molecule
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Discover the
scandinavian
BIO-SCIENCETM

DISCOVER THE SCANDINAVIAN BIO-SCIENCETM

THE MOUTH’S
DEFENCE SYSTEM

In addition to keeping the whole mouth
clean and lubricated, saliva is a versatile
protector - creating a natural oral defence
system. It contains a variety of protective
components, including vital enzymes and
proteins, which help maintain a healthy
oral microflora.2,6 In saliva, enzymes can act
in a cascade to catalyse the natural
formation of hypothiocyanite, via
hydrogen peroxide. Hypothiocyanite is a
key antimicrobial component in the
mouth.6 Levels of hydrogen peroxide
naturally contained in the mouth are often
too low to trigger the enzymatic reaction.7

Image Showing the Function of Saliva

ZENDIUM'S ENZYME
AND PROTEIN SYSTEM

Zendium’s triple enzyme system of
amyloglucosidase, glucose oxidase and
lactoperoxidase can lead to the formation
of hydrogen peroxide, which ultimately
drives the production of
hypothiocyanite.3,10 Zendium also contains
three other ingredients that can be found
naturally in saliva, where they inhibit
bacterial growth. Lysozyme, lactoferrin
and colostrum as a source of IgG, an
immunoglobulin, work in harmony with
the lactoperoxidase system to boost the
mouth’s natural defences.3,4,6

ZENDIUM IS
CLINICALLY PROVEN

In a clinical study, levels of hydrogen
peroxide in the saliva were significantly
higher after brushing with Zendium
compared with a standard fluoride
toothpaste (P = 0.007).10 Hydrogen
peroxide is key to driving the
lactoperoxidase system and the
production of hypothiocyanite.3,7

zendium

SUITABLE FOR A SENSITIVE
ORAL MUCOSA

Zendium’s specially designed formulation
is suitable for those with a sensitive oral
mucosa. A published study comparing
Zendium with other toothpastes confirms
that Zendium can be used by people with
recurrent aphthous ulcers.13

REFERENCES

  1. Pedersen AML. Saliva. 2007.
  2. Amerongen A & Veerman E. Saliva – the defender of the oral cavity. Oral Dis 2002;8:12–22.
  3. Lenander-Lumikari M, et al. Lysozyme enhances the inhibitory effects of the peroxidase system on glucose metabolism of Streptococcus mutans.
    J Dent Res 1992;71:484–490.
  4. Berlutti F, et al. Both lactoferrin and iron influence aggregation and biofilm formation in Streptococcus mutans. BioMetals 2004;17:271–278.
  5. Frenkel E & Ribbeck K. Salivary mucins protect surfaces from colonization by cariogenic bacteria. Appl Environ Microbiol 2014; epub ahead of print.
  6. Van’t Hof W, et al. Antimicrobial defence systems in saliva. Monogr Oral Sci 2014;24:40–51.
  7. Midda M & Cooksey M. Clinical uses of an enzyme-containing dentrifice. J Clin Perio 1986;13:950–956.
  8. Hayes ML. A lactate oxidase-salivary peroxidase-thiocyanate antibacterial enzyme system. Microbiol Ecol Health Dis 1996;9:321–328.
  9. Rosema NAM, et al. Dentifrice with colostrum and the treatment of plaque and gingivitis. IADR 2007, Thessaloniki, Greece. Poster.
  10. Unilever, data on file
  11. Unilever, data on file.
  12. Arenholdt-Bindslev D et al. Toxicity of sodium dodecyl sulphate and other detergents in cultures of human oral mucose epithelium.
    ATLA 1992;20:28–38.
  13. Barkvoll P. A possible oral health effect of colostrum containing dentifrices. J Dent Res 2005;84(Spec Iss B):505.